St. Louis-to-Indianapolis dir

This time we are looking on the crossword puzzle clue for: St. Louis-to-Indianapolis dir.
it’s A 29 letters crossword definition.
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Possible Answers:

ENE.

Last seen on: Universal Crossword – Jun 28 2022 s

Random information on the term “ENE”:

Ene is both a given name and a surname.

ENE on Wikipedia