Military echelon

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it’s A 16 letters crossword puzzle definition. See the possibilities below.

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Possible Answers: RANK.

Random information on the term “RANK”:

3M0D

7185

22029

ENSG00000056558

ENSMUSG00000026875

Q13077

P39428

NM_005658
NM_001190945
NM_001190947

NM_009421
NM_001326601

NP_001177874
NP_001177876
NP_005649

NP_033447.2
NP_001313530
NP_033447

TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. TRAF1 also functions as a negative regulator of inflammation by interfering with the linear ubiquitination of NEMO downstream of TLR signaling. This explains why TRAF1 polymorphisms cause an increased risk for rheumatic diseases.

RANK on Wikipedia

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