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Last seen on: –LA Times Crossword 25 Nov 21, Thursday
Eugene Sheffer – King Feature Syndicate Crossword – Nov 27 2020
NY Times Crossword 12 Jul 19, Friday
Daily Celebrity Crossword – 10/22/18 Movie Monday

Random information on the term “ASS”:

The donkey or ass (Equus africanus asinus) is a domesticated member of the horse family, Equidae. The wild ancestor of the donkey is the African wild ass, E. africanus. The donkey has been used as a working animal for at least 5000 years. There are more than 40 million donkeys in the world, mostly in underdeveloped countries, where they are used principally as draught or pack animals. Working donkeys are often associated with those living at or below subsistence levels. Small numbers of donkeys are kept for breeding or as pets in developed countries.

A male donkey or ass is called a jack, a female a jenny or jennet; a young donkey is a foal. Jack donkeys are often used to mate with female horses to produce mules; the biological “reciprocal” of a mule, from a stallion and jenny as its parents instead, is called a hinny.

Asses were first domesticated around 3000 BC, probably in Egypt or Mesopotamia, and have spread around the world. They continue to fill important roles in many places today. While domesticated species are increasing in numbers, the African wild ass is an endangered species. As beasts of burden and companions, asses and donkeys have worked together with humans for millennia.

ASS on Wikipedia

Random information on the term “ALSO”:

An emergency department (ED), also known as an accident & emergency department (A&E), emergency room (ER), emergency ward (EW) or casualty department, is a medical treatment facility specializing in emergency medicine, the acute care of patients who present without prior appointment; either by their own means or by that of an ambulance. The emergency department is usually found in a hospital or other primary care center.

Due to the unplanned nature of patient attendance, the department must provide initial treatment for a broad spectrum of illnesses and injuries, some of which may be life-threatening and require immediate attention. In some countries, emergency departments have become important entry points for those without other means of access to medical care.

The emergency departments of most hospitals operate 24 hours a day, although staffing levels may be varied in an attempt to reflect patient volume.

Accident services were already provided by workmen’s compensation plans, railway companies, and municipalities in Europe and the United States by the late mid-nineteenth century, but the first specialized trauma care center in the world was opened in 1911 in the United States at the University of Louisville Hospital in Louisville, Kentucky, and was developed by surgeon Arnold Griswold during the 1930s. Griswold also equipped police and fire vehicles with medical supplies and trained officers to give emergency care while en route to the hospital.

ALSO on Wikipedia

Random information on the term “SAP”:

4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV











The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.

AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.

SAP on Wikipedia

Random information on the term “NERD”:

N*E*R*D (a backronym of No-one Ever Really Dies) is an American funk rock band. Pharrell Williams and Chad Hugo were signed by Teddy Riley to Virgin Records as a duo, The Neptunes. After producing songs for several artists throughout the late 1990s and early 2000s, the production duo formed the band with Sarah Atyat Williams as a side project of The Neptunes in 1999. N*E*R*D’s debut album, In Search Of…, sold 603,000 copies in the United States and was certified Gold by the Recording Industry Association of America (RIAA). It was also awarded the second annual Shortlist Music Prize. The band’s second album, Fly or Die, sold 412,000 copies in the United States, but shipped at least 500,000 units, certifying it Gold.

In 2005, N*E*R*D ended their contract with Virgin and disbanded. Three years later, the band reunited under Star Trak Entertainment, a subsidiary of Interscope Records established by Williams and Hugo. The band’s third album, Seeing Sounds, released in 2008, sold just under 80,000 copies in its first week. The album was followed by Nothing, which was released in 2010.

NERD on Wikipedia

Random information on the term “ZERO”:

In complex analysis, a zero (sometimes called a root) of a holomorphic function f is a complex number a such that f(a) = 0.

A complex number a is a simple zero of f, or a zero of multiplicity 1 of f, if f can be written as

where g is a holomorphic function such that g(a) is nonzero.

Generally, the multiplicity of the zero of f at a is the positive integer n for which there is a holomorphic function g such that

The multiplicity of a zero a is also known as the order of vanishing of the function at a.

The fundamental theorem of algebra says that every nonconstant polynomial with complex coefficients has at least one zero in the complex plane. This is in contrast to the situation with real zeros: some polynomial functions with real coefficients have no real zeros. An example is f(x) = x2 + 1.

An important property of the set of zeros of a holomorphic function of one variable (that is not identically zero) is that the zeros are isolated. In other words, for any zero of a holomorphic function there is a small disc around the zero which contains no other zeros. There are also some theorems in complex analysis which show the connections between the zeros of a holomorphic (or meromorphic) function and other properties of the function. In particular Jensen’s formula and Weierstrass factorization theorem are results for complex functions which have no counterpart for functions of a real variable.

ZERO on Wikipedia

Random information on the term “DRIP”:

Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in the lab of Roger D. Kornberg, winner of the 2006 Nobel Prize in Chemistry. Mediator[a] complexes interact with transcription factors and RNA polymerase II. The main (but not exclusive) function of mediator complexes is to transmit signals from the transcription factors to the polymerase.

Mediator complexes are variable at the evolutionary, compositional and conformational levels. The first image shows only one “snapshot” of what a particular mediator complex might be composed of,[b] but it certainly does not accurately depict the conformation of the complex in vivo. During evolution, mediator has become more complex. The yeast Saccharomyces cerevisiae (a simple eukaryote) is thought to have up to 21 subunits in the core mediator (exclusive of the CDK module), while mammals have up to 26.

Individual subunits can be absent or replaced by other subunits under different conditions. Also, there are many intrinsically disordered regions in mediator proteins, which may contribute to the conformational flexibility seen both with and without other bound proteins or protein complexes. A more realistic model of a mediator complex without the CDK module is shown in the second figure.

DRIP on Wikipedia

Random information on the term “CREEP”:

President of the United States

First term

Second term


The presidency of Richard Nixon began on January 20, 1969, when he was inaugurated, and ended on August 9, 1974, when he resigned in the face of almost certain impeachment and removal from office, the first U.S. president ever to do so. He was succeeded by Vice President Gerald Ford, who had become vice president nine months earlier, following Spiro Agnew’s resignation from office. A Republican, Nixon took office after the 1968 presidential election, in which he defeated Hubert Humphrey, the then–incumbent Vice President. Four years later, in 1972, Nixon won reelection in a landslide victory over George McGovern.

Nixon, the 37th United States president, succeeded Lyndon B. Johnson, who had launched the Great Society, a set of domestic programs financed and run by the federal government. In contrast, Nixon advocated a “New Federalism” domestic program model, one in which certain powers would devolve back to the states. The creation of the EPA, passage of the Endangered Species Act, and the integration of Southern public schools happened during his presidency, as did the end of military draft and the Apollo program, which successfully landed Americans on the Moon.

CREEP on Wikipedia