Dull pain

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Possible Answers: ACHE.

Last seen on: –Eugene Sheffer – King Feature Syndicate Crossword – Dec 17 2020
Thomas Joseph – King Feature Syndicate Crossword – Dec 8 2020
USA Today Crossword – Aug 31 2020
Jonesin’ – Apr 28 2020
USA Today Crossword – Mar 31 2020
Thomas Joseph – King Feature Syndicate Crossword – Mar 9 2020
Universal Crossword – Feb 13 2020
USA Today Crossword – Dec 26 2019
Thomas Joseph – King Feature Syndicate Crossword – Dec 9 2019
Daily Celebrity Crossword – 11/18/19 Movie Monday
Thomas Joseph – King Feature Syndicate Crossword – Aug 26 2019
Thomas Joseph – King Feature Syndicate Crossword – Feb 19 2019
Universal Crossword – Oct 10 2018
Eugene Sheffer – King Feature Syndicate Crossword – Sep 15 2018

Random information on the term “ACHE”:

An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

Acetylcholinesterase inhibitors:

Some major effects of cholinesterase inhibitors:

Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.

When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).

ACHE on Wikipedia