This time we are looking on the crossword clue for: Deplete.
it’s A 7 letters crossword puzzle definition. See the possibilities below.
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Possible Answers: SAP, SPEND, EMPTY, DRAIN, USEUP, EATINTO, EXHAUST, USEBUP.
Last seen on: –NY Times Crossword 21 Jul 20, Tuesday
–USA Today Crossword – Mar 23 2020
–Thomas Joseph – King Feature Syndicate Crossword – Oct 23 2019
–Universal Crossword – Dec 22 2018
–Newsday.com Crossword – Nov 20 2018
–Thomas Joseph – King Feature Syndicate Crossword – Oct 11 2018
–Premier Sunday – King Feature Syndicate Crossword – Sep 9 2018
Random information on the term “SAP”:
4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV
The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.
AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.