Deplete

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it’s A 7 letters crossword puzzle definition. See the possibilities below.

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Possible Answers: SAP, SPEND, EMPTY, DRAIN, USEUP, EATINTO, EXHAUST, USEBUP.

Last seen on: –NY Times Crossword 21 Jul 20, Tuesday
USA Today Crossword – Mar 23 2020
Thomas Joseph – King Feature Syndicate Crossword – Oct 23 2019
Universal Crossword – Dec 22 2018
Newsday.com Crossword – Nov 20 2018
Thomas Joseph – King Feature Syndicate Crossword – Oct 11 2018
Premier Sunday – King Feature Syndicate Crossword – Sep 9 2018

Random information on the term “SAP”:

4AYU, 1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV

325

20219

ENSG00000132703

ENSMUSG00000026542

P02743

P12246

NM_001639

NM_011318

NP_001630

NP_035448.2
NP_035448

The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called “amyloid”. APCS is its human gene.

AP makes up 14% of the dry mass of amyloid deposits and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses. These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms. This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition. The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.

SAP on Wikipedia