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Last seen on: –LA Times Crossword 15 Dec 20, Tuesday
The Washington Post Crossword – Dec 15 2020
NY Times Crossword 14 Nov 20, Saturday
USA Today Crossword – Mar 30 2020
NY Times Crossword 5 Jul 19, Friday

Random information on the term “ICE”:

1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA











Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.

ICE on Wikipedia

Random information on the term “REST”:

Scalability is the capability of a system, network, or process to handle a growing amount of work, or its potential to be enlarged to accommodate that growth. For example, a system is considered scalable if it is capable of increasing its total output under an increased load when resources (typically hardware) are added. An analogous meaning is implied when the word is used in an economic context, where a company’s scalability implies that the underlying business model offers the potential for economic growth within the company.

Scalability, as a property of systems, is generally difficult to define and in any particular case it is necessary to define the specific requirements for scalability on those dimensions that are deemed important. It is a highly significant issue in electronics systems, databases, routers, and networking. A system whose performance improves after adding hardware, proportionally to the capacity added, is said to be a scalable system.

An algorithm, design, networking protocol, program, or other system is said to scale if it is suitably efficient and practical when applied to large situations (e.g. a large input data set, a large number of outputs or users, or a large number of participating nodes in the case of a distributed system). If the design or system fails when a quantity increases, it does not scale. In practice, if there are a large number of things (n) that affect scaling, then resource requirements (for example, algorithmic time-complexity) must grow less than n2 as n increases. An example is a search engine, which scales not only for the number of users, but also for the number of objects it indexes. Scalability refers to the ability of a site to increase in size as demand warrants.

REST on Wikipedia

Random information on the term “NIP”:

Public nudity, or nude in public (NIP), refers to nudity not in an entirely private context, that is, a person appearing nude in a public place or being able to be seen nude from a public place. Nudity on private property but where the general public is commonly free to enter, such as a shopping mall, public transport or swimming pool, is also considered public nudity. Nudity in the privacy of a person’s home or grounds is not considered public nudity, nor is nudity at privately owned facilities where nudity commonly takes place, such as gymnasia, locker rooms, saunas, or specific nudist clubs or resorts. Naturism is a movement that promotes social nudity in nature, most but not all of which takes place on private property.

Not all people who engage in public nude events see themselves as naturists or belong to traditional naturist or nudist organizations. Some activists, such as Vincent Bethell, claim that association with naturism or nudism is unnecessary. Others will point out that many people who participate in events such as clothing-optional bike rides or visit clothing-optional beaches do so casually and without association or formal affiliation to groups or movements. Activist Daniel Johnson believes that labels and affiliations overly complicate a relatively simple phenomenon, alienate others from a fear of over-commitment or undesirable stereotypes, and thus get in the way of integrating nudity into everyday life.

NIP on Wikipedia

Random information on the term “RELAX”:

In computing, RELAX NG (REgular LAnguage for XML Next Generation) is a schema language for XML – a RELAX NG schema specifies a pattern for the structure and content of an XML document. A RELAX NG schema is itself an XML document but RELAX NG also offers a popular compact, non-XML syntax. Compared to other XML schema languages RELAX NG is considered relatively simple.

It was defined by a committee specification of the OASIS RELAX NG technical committee in 2001 and 2002, based on Murata Makoto’s RELAX and James Clark’s TREX, and also by part two of the international standard ISO/IEC 19757: Document Schema Definition Languages (DSDL). ISO/IEC 19757-2 was developed by ISO/IEC JTC1/SC34 and published in its first version in 2003.

Suppose we want to define an extremely simple XML markup scheme for a book: a book is defined as a sequence of one or more pages; each page contains text only. A sample XML document instance might be:

A RELAX NG schema can be written in a nested structure by defining a root element that contains further element definitions, which may themselves contain embedded definitions. A schema for our book in this style, using the full XML syntax, would be written:

RELAX on Wikipedia

Random information on the term “FROST”:

This category has the following 6 subcategories, out of 6 total.

The following 200 pages are in this category, out of 337 total. This list may not reflect recent changes (learn more).

FROST on Wikipedia

Random information on the term “ALGOR”:

Advanced Simulation Library (ASL) is free and open source hardware accelerated multiphysics simulation platform. It enables users to write customized numerical solvers in C++ and deploy them on a variety of massively parallel architectures, ranging from inexpensive FPGAs, DSPs and GPUs up to heterogeneous clusters and supercomputers. Its internal computational engine is written in OpenCL and utilizes matrix-free solution techniques. ASL implements variety of modern numerical methods, i.a. Level set method, Lattice Boltzmann, Immersed Boundary. Mesh-free, immersed boundary approach allows to move from CAD directly to simulation reducing pre-processing efforts and amount of potential errors. ASL can be used to model various coupled physical and chemical phenomena, especially in the field of Computational fluid dynamics. It is distributed under the free GNU Affero General Public License with an optional commercial license (which is based on the permissive MIT License).

Advanced Simulation Library is being developed by Avtech Scientific, an Israeli company. Its source code was released to the community on 14 May 2015 whose members packaged it for scientific sections of all major Linux distributions shortly thereafter. Subsequently, Khronos Group acknowledged the significance of ASL and listed it on its website among OpenCL-based resources.

ALGOR on Wikipedia